The Anderson family, particularly R. C. Anderson, Jr. and his wife Elizabeth and their tour of duty in Colombia. Anderson Senior, his other sons Charles and Robert (of Ft. Sumter fame), and Larz; the Clark and Gwathmey families; real estate transactions, legislation, and speculation in Kentucky; Louisville and Kentucky politics; some national politics; relations between Colombia and the U.S.; antislavery sentiment; the Civil War; Ohio politics and government, especially during the Civil War

Richard Clough Anderson, statesman and diplomat, was born in Louisville, Kentucky, to Richard Clough Anderson (1750-1826), a Virginia Revolutionary officer, and Elizabeth Clark, sister of George Roger Clark. After studying law under St. George Tucker, he opened a practice in Louisville. He held a seat in the state House of Representatives from 1812 to 1816, and again from 1821 to 1823, when he chaired the Committee on Public lands. From 1817 to 1821, he served in the U.S. Congress, where he distinguished himself as an advocate of Latin-American independence. President Monroe appointed him minister plenipotentiary to La Gran Colombia in 1823, a post he held until his untimely death caused by a fever he contracted while serving as a minister.

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